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What is Cancer Zcreen ?

Cancer Zcreen enable an accurate prediction of the disease risk and effective follow-up interventions.

Individuals with the BRCA1 mutation have a substantially increased risk of developing Breast and Ovarian Cancer, often before the age of 50. 80% of the patients with a family history of Breast Cancer and/or Ovarian Cancer carry the BRCA1/2 mutation. However, early detection followed by preventive and prophylactic methods have been shown to reduce the risk by as much as 90%. Zentrogene a comprehensive test for Breast and Ovarian Cancers by covering 21 (including BRCA1/2) cancer-related genes, thereby allowing an accurate prediction of the disease risk.

Colorectal Cancer (CRC) occurs in the colon or rectum; 10% of CRC patients are caused by the hereditary form which mainly consist of Familial Adenomatous Polyposis (FAP) and Hereditary Nonpolyposis Colorectal Cancer (HNPCC).

FAP is caused by mutations of the APC gene while HNPCC is associated with mutations of MMR (MLH1, MSH2, MSH6, PMS2). Left untreated, an FAP patient has a 93% chance of developing CRC before the age of 50; and carriers of the MMR mutations have an 80% lifetime risk of CRC with an average onset age at 44 years. Genetic testing for Hereditary Colorectal Cancer detects mutations in 14 disease-related genes including APC and MMR, which enables early prediction of the disease risk and effective follow-up interventions.

The advantages of Cancer Zcreen

Convenient

Only 5ml peripheral blood

Highly Accurate

High accuracy (99.9%) by utilizing chip capture and NGS, with Sanger sequencing validated

Full Coverage

All types of mutation
(point mutations indels, repeats)

Professional

A professional team for genetic analysis

How to get tested?

Easy to be tested, easy to understand

Pre-test
Counseling

Information
Consent

Blood Drawing

Laboratory
Testing

Report Delivery

Post-test
Counseling

The science behind Cancer Zcreen

By utilizing the technique of chip capture and massively parallel sequencing (next generation sequencing), all exons and splicing sites of tested genes are analyzed.

Fragmentation

Adapter Ligation

Chip
Hybridization

Washing

PCR

Sequencing &
Analysis

Case Study :

Name: A
Gender: Female
Clinical Symptom:
Diagnosed with breast cancer at age of 40 years old.
Family History:
Mother had breast cancer at age of 50 years old.
Test taken:
BRCA 1/2 genetic testing.

Interpretation:

A frameshift (c.335_335delA) was detected in the region of no.5 exon of, leading to protein synthesis termination ahead of time. This coding area is supposed to code 1863 amnio acid, however in this case, it only codes 117 amnio acid due to this frameshift, which eventually causes protein inactivation, losing its function in DNA damage repairmen, tumor suppression, and signal transmisson.

According to A’s family history, her mother and sister are also recommended to take validation of this mutation. The result shows that both of them carry the same frameshift mutation.

Finally, the real cause of cancer in this family is discovered and at the same time, test result prompts that her sister is at increased risk of developing breast/ovarian or related cancers.

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